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Routes of AdministrationTo Top

8948034_xxlNBR scientists have utilized a number of routes of administration in non-human primate, canine, rodent, ovine and lagomorph models. The core of NBR expertise is targeted delivery to the CNS through an implanted catheter that terminates in an external infusion pump, subcutaneous access port, or implantable osmotic or mechanical infusion pump. NBR investigators are constantly evaluating novel routes of administration to meet the needs of clients. Available routes of administration include:

  • Intrathecal Lumbar
  • Intracerebroventricular
  • Intraparenchymal
  • Perineural
  • Ocular (Intravitreal, Anterior Chamber, Intra-Optic Nerve, Conjuctival)
  • Epidural
  • Oral
  • Parenteral

Test ArticlesTo Top

From oligonucleotides to recombinant proteins and viral vectors, NBR has extensive experience working with a broad range of compounds and vehicles specially designed for targeted delivery to the CNS. Access to test articles and vehicles is limited to essential personnel. Storage conditions are controlled and monitored. Test articles include:

  • Small molecules
  • Recombinant proteins
  • Peptides
  • Oligonucleotides
  • Gene therapy vehicles
  • Cell implants

DevicesTo Top

NBR scientists have tested a number of novel devices and are experts at choosing the optimal device for a given application, considering multiple parameters such as function (dosing or sampling), route of administration, dosing regimen, test article characteristics and animal model. Devices evaluated and/or utilized by NBR include:

  • Specialty implantable catheters
  • Subcutaneous access ports
  • Implantable pumps
  • Ambulatory external pumps
  • Intracranial pressure monitors