NBR is equipped with an on-site MRI unit to meet all imaging needs. Located in its own bay with dedicated electrical and environmental controls, the Philips 3.0T Achieva X series unit combines a user friendly interface and decreased scanning time with superb image quality. Whether it is immediate access for acute imaging or the collection of longitudinal study data, the state of the art scanner offers a wide range of applications designed to meet study specific goals. A variety of interchangeable imaging coils and various imaging modalities allow the experienced technical staff to tailor a specific scanning protocol to meet individual research needs.
MRI cartography guides NBR’s intraparenchymal and intracebroventricular stereotaxic surgical procedures. Study specific imaging protocols are developed to collect and characterize longitudinal study data. NBR is currently working to develop a real time, MRI guided intraparenchymal or intracerebroventricular drug delivery platform. Specialty imaging modalities are also available including whole body imaging (MobiView), diffusion tensor imaging (DTI – Fiber Tracking) and spectroscopy. The 3.0T clinical scanner is also capable of performing fMRI, angiography, DWIBS (diffusion-weighted whole-body imaging with background body signal suppression) and has a complete cardiac package installed. Studies have been performed in multiple species utilizing the MRI to track test article distribution following bolus or continuous administration via ICV or IT-L administration.
MobiView - Whole Body ImagingTo Top
With the ability to scan using two imaging coils simultaneously (e.g Neurovascular Head and Neurovascular Spine coils), data is collected utilizing a moving table during the scanning procedure. The images are merged during post processing to achieve a complete body image.
DTI - Fiber TrackingTo Top
Diffusion tensor imaging allows the mapping of the diffusion process of molecules, mainly water, in biological tissues. Because it can reveal abnormalities in the white matter fiber structure and provide models of brain connectivity, it is an invaluable tool for the diagnosis of disorders affecting the white matter of the brain. It has also been utilized in the study and treatment of other neurological disorders such as acute stroke.
Spectroscopy is utilized to study the metabolic changes in select brain regions. It has several applications and has been used to study brain tumors, seizure disorders, Alzheimer’s disease, depression and other diseases affecting the brain. Both magnetic resonance spectroscopy and MRI utilize signals from hydrogen protons in the brain. MRI uses these signals to create a two dimensional image of the brain, while spectroscopy uses them to determine relative concentrations of single or multi-voxel targets.